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KMID : 0388120090180040131
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Journal of Korean Society for the Study of Obesity
2009 Volume.18 No. 4 p.131 ~ p.137
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C-reactive protein and obesity
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Ahn Keun-Yung
Choi Youn-Seon
Lee Ding-Won
Kim Kun-Young
Kim Jung-Hyean
Sung Han-Na
Choi Kyung-Mook
Kim Seon-Mee
Lee Chang-Beom
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Abstract
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Background: low grade inflammation has been proposed as a pathophysiologic mechanism of obesity. Thus, we sought to determine the relation of C-reactive protein to obesity in Korean children.
Methods: we selected 585 children aged 9 years in Seoul. Anthropometric measurements and fasting blood samples were collected and body mass index (BMI) was calculated as weight/height2. We measured high-sensitivity CRP(hs-CRP), glucose(FBS), total cholesterol(TC), high density lipoprotein cholesterol(HDL-C), and triglyceride(TG).
Results: hs-CRP concentration was positively correlated with weight, BMI, waist circumference and negatively correlated with HDL-C. On multivariate analysis, these variables emerged as independent determinants of hs-CRP concentration.
Conclusion: obesity is associated with higher hs-CRP concentration. These findings suggest a state of subclinical inflammation in obese children.
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KEYWORD
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obesity, child, C-reactive protein
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